Hypopituitarism, or underactive pituitary gland, occurs when the pituitary gland does not produce enough hormones. It is a rare medical disease. The pituitary gland located beneath the brain is called the main gland It also regulates other hormone-producing glands. These other glands are the thyroid, adrenal glands, and the genitals. Gradual or sudden impact the pituitary gland is Important for controlling water balance, blood pressure, sex, response to stress. and basic metabolism in the condition of the pituitary gland malfunctioning These hormones cannot be released.